| City: | Cincinnati, Ohio |
| Names to Avoid: | University Of Cincinnati |
| County: | Hamilton County |
| Timezone: | Eastern (GMT -05:00) |
| Local Time: | 9:52:01 PM |
| Population: | No Population Data |
| Area Codes: | 283 / 513 |
| Classification: | Unique [Company/Government] |
| Coordinates: | 39.1616, -84.4569 |
| Quick Link: |
The University of Cincinnati operates under dedicated ZIP code 45221 in Hamilton County, Ohio. Founded in 1819, UC ranks among Ohio's oldest and most prestigious universities. The institution pioneered cooperative education in 1906 through its College of Engineering, creating a model now used by universities worldwide. Notable contributions include the development of the oral polio vaccine by Dr. Albert Sabin and the first antihistamine. With over 53,000 students, UC thrives in Cincinnati's Corryville neighborhood.
This unique postal designation has served the university for over two decades. Just 3 ZIP+4 codes route mail to campus operations, suggesting centralized mail handling. Census County Business Patterns data shows 16 establishments and 416 employees within this specific designation. Cincinnati serves as the valid mailing city for correspondence to this major research university.
| Establishments: | 16 |
| Employment: | 416 |
ZIP Code 45221 supports both business and residential activity. According to the Business Census (2024), there are 16 business establishments, employing about 500 people with an annual payroll of $23,481,000.
| # Residential Mailboxes: | 0Source: USPS |
| # Business Mailboxes: | 0Source: USPS |
| Total Delivery Receptacles: | 115Source: USPS |
| Single Family Delivery Units: | 0Source: USPS |
| Multi Family Delivery Units: | 0Source: USPS |
| # of Businesses: | 16Source: CBP |
| 1st Quarter Payroll: | $5,517,000Source: CBP |
| Annual Payroll: | $23,481,000Source: CBP |
| # of Employees: | 500Source: CBP |
ZIP Code 45221 is located in Hamilton County, Ohio, within the Cincinnati, OH-KY-IN Metropolitan Statistical Area (CBSA 17140) and Ohio's 1st Congressional District. This Metro area has a population of 2,130,151 people, about 0.00% of whom live in ZIP Code 45221. It covers 0 sq mi of land and a water area of 0 sq mi.
| CBSA Name: | Cincinnati, OH-KY-INSource: Census |
| CBSA Number: | 17140Source: Census |
| CBSA Type: | MetroSource: Census |
| CBSA Division: | --Source: Census |
| CBSA Population: | 2,130,151Source: Census |
| MSA: | Cincinnati-Hamilton, OH-KY-IN CMSASource: Census |
| Land Area: | --Source: Census |
| Water Area: | --Source: Census |
| Congressional District: | 01Source: USPS |
| Congressional Land Area: | 686.96 sq miSource: Census |
| PMSA: | Cincinnati, OH-KY-IN PMSASource: Census |
| Intro Date: | < 2004-10Source: ZIP-Codes.com |
| Place FIPS Code: | 3915000Source: Census |
| Place Name: | Cincinnati city; OhioSource: Census |
We could not locate which school district 45221 belongs to, but we will update this once new district data is released. There are no public schools nor private schools with a mailing address in this ZIP Code. Listing Nearby schools instead. It also has 6 colleges, universities or post secondary education institutions nearby which would be a short commute to.
Our sources include trusted federal and licensed data from the United States Postal Service, U.S. Census Bureau, U.S. Geological Survey, Centers for Medicare & Medicaid Services, and the National Center for Education Statistics, along with proprietary datasets created by ZIP-Codes.com. Data last updated on February 1, 2026.