ZIP Codes of Audrain County, MO

Population & People
Population & People
Total Population
22,314
Household Income
Household Income
Median Income
$67,116
Housing
Housing
Total Housing Units
10,006
Business & Economy
Business & Economy
Total Businesses
464
Employment
Employment
Employment Rate
52.27%
Education
Education
Bachelor's Degree+
16.36%
Source: U.S. Census ACS 2024 5-Year Estimates · rolled up across the 8 ZIPs in this county.
Data Last Updated: June 1, 2026
ZIP Codes:8 ZIP Codes (8 Standard, 0 PO Box, 0 Unique) [See All]
Area Codes:235 / 573
Timezone:Central (GMT -06:00)
Local Time:2:12:40 PM
Population:22,314 [See All]
FIPS:29007
CBSA:Mexico, MO
Land Area:643 sq mi
Water Area:5 sq mi
Coordinates:39.2137, -91.7291
Quick Link:
https://www.zip-codes.com/county/mo-audrain.asp
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Missouri's #48 most populous county
22,314 residents across 8 ZIPs — #48 of 116 Missouri counties.

Standout ZIPs in this County


Most Populous
Mexico · 15,153 people
67.9% of county total
Highest Income
Thompson · $98,625 median
1.5× county average
Largest Land Area
Mexico · 223.0 sq mi
Spans the most ground
Fastest Growth
Mexico · -0.6% (10-yr)
15,252 → 15,153 residents
Most Educated
Mexico · 19.6% bachelor's+
2,070 of 10,576 adults 25+

Things worth knowing about Audrain County


22,314 residents live across 8 ZIPs covering 643 sq mi, served by 8 distinct USPS-recognized cities.

Population moved from 24,041 to 22,314 from 2014 to 2024 — a -7.2% change. 2 ZIPs gained residents, 6 lost.

The county's wealthiest ZIP 65285 (Thompson, $98,625 median) and poorest ZIP 63345 (Farber, $43,500) are 22.2 miles apart — a 2.3× income gap across local geography.

Median home values vary 2.7× across this county — from $80,300 in 63345 (Farber) to $220,800 in 65285 (Thompson).

Density varies 12× across the county — from 5 people/sq mi in 65280 (Rush Hill) to 68 in 65265 (Mexico).

Educational attainment ranges from 6.0% bachelor's+ in 63345 (Farber) to 19.6% in 65265 (Mexico) — the breadth of educational profiles across the area.

Within Missouri, this is the #48 most populous of 116 counties and ranks #37 for median household income .

Weighted by population, the typical household earns about $58,387 across the county — reflecting what a typical resident sees, not a simple ZIP average.

16.4% of adults age 25+ hold a bachelor's degree or higher (2,623 of 16,032 reporting).

8 Standard delivery, 0 PO Box only, 0 single-entity Unique ZIPs serve this county.

Stories about Audrain County


Big & sparse

A frontier county — vast land area with only a few residents per square mile. Daily life looks very different here than in the country's denser counties.

Total area
643
square miles
Avg density
34.7
people per sq mi
Population
22,314
across 8 ZIPs
Mexico
223.0 sq mi
15,153 residents
Vandalia
129.8 sq mi
4,033 residents
Laddonia
108.6 sq mi
1,018 residents

Single-ZIP anchor

One ZIP holds the majority of this county's population — a sign of a county built around a single city or town.

Mexico

Population decline

Audrain County lost 7.2% of residents between 2014 and 2024. ZIPs that shed the largest share:

Farber
-46.2%
541 → 291 residents
Thompson
-41.6%
896 → 523 residents
Vandalia
-21.2%
5,118 → 4,033 residents

All ZIP Codes in Audrain County


ZIPCityTypePopulationMedian IncomeArea (sq mi)10-yr Growth
65265MexicoStandard15,153$56,969223.0-0.6%
63382VandaliaStandard4,033$60,733129.8-21.2%
63352LaddoniaStandard1,018$54,485108.6-3.8%
65264MartinsburgStandard919$46,04260.831.1%
65285ThompsonStandard523$98,62554.8-41.6%
63345FarberStandard291$43,50021.8-46.2%
65232Benton CityStandard256$83,54222.52.8%
65280Rush HillStandard121$93,03622.1-46.5%

Adjacent & Nearby Counties